Terbinafine inhibits Cryptococcus neoformans growth and modulates fungal morphology
نویسندگان
چکیده
منابع مشابه
Terbinafine inhibits Cryptococcus neoformans growth and modulates fungal morphology.
Cryptococcus neoformans is an encapsulated fungus that causes cryptococcosis. Central nervous system infection is the most common clinical presentation followed by pulmonary, skin and eye manifestations. Cryptococcosis is primarily treated with amphotericin B (AMB), fluconazole (FLC) and itraconazole (ITC). In the present work, we evaluated the in vitro effect of terbinafine (TRB), an antifunga...
متن کاملCryptococcus neoformans of unusual morphology.
A case of primary cryptococcosis of the lungs was caused by an isolate of Cryptococcus neoformans that assumes a giant form in tissue but which has a normal appearance on artificial culture. Electron microscopy revealed gross enlargement of the capsule and plasma membranes in the tissue form.
متن کاملCryptococcus Neoformans Modulates Extracellular Killing by Neutrophils
We recently established a key role for host sphingomyelin synthase (SMS) in regulating the killing activity of neutrophils against Cryptococcus neoformans. In this paper, we studied the effect of C. neoformans on the killing activity of neutrophils and whether SMS would still be a player against C. neoformans in immunocompromised mice lacking T and natural killer (NK) cells (Tgε26 mice). To thi...
متن کاملAb binding alters gene expression in Cryptococcus neoformans and directly modulates fungal metabolism.
Abs facilitate humoral immunity via the classical mechanisms of opsonization, complement activation, Ab-dependent cellular cytotoxicity, and toxin/viral neutralization. There is also evidence that some Abs mediate direct antimicrobial effects. For example, Ab binding to the polysaccharide capsule of the human pathogenic fungus Cryptococcus neoformans promotes opsonization but also inhibits poly...
متن کاملHuman antibodies against a purified glucosylceramide from Cryptococcus neoformans inhibit cell budding and fungal growth.
A major ceramide monohexoside (CMH) was purified from lipidic extracts of Cryptococcus neoformans. This molecule was analyzed by high-performance thin-layer chromatography (HPTLC), gas chromatography coupled with mass spectrometry, and fast atom bombardment-mass spectrometry. The cryptococcal CMH is a beta-glucosylceramide, with the carbohydrate residue attached to 9-methyl-4,8-sphingadienine i...
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ژورنال
عنوان ژورنال: Memórias do Instituto Oswaldo Cruz
سال: 2012
ISSN: 0074-0276
DOI: 10.1590/s0074-02762012000500003